Sanctum

What it is

Sanctum is a roguelite area with multiple floors. Each floor is a grid of rooms — you choose your path and fight through rooms, gaining Boons (permanent buffs for the run) and managing your Resolve (a second HP pool separate from life). If Resolve hits zero, you're ejected from the Sanctum. The final boss drops the Hallow of the Fanatic and other valuable unique items.

When you encounter it

Sanctum portals appear in maps. Lycia, the NPC, sells Sanctum-related items. You can also get Sanctum Map items.

Key concepts

• •Resolve is separate from your life — Afflictions can drain it even if you don't die normally
• •Afflictions are debuffs applied in rooms that persist for the floor — avoid as many as you can
• •Boons are positive room rewards — prioritize Boons over Gold when Resolve is healthy
• •Coins (the Sanctum currency) are spent in merchant rooms inside the Sanctum
• •The Orb of Dominance floor boss can be skipped or fought — killing it gives extra rewards

Tips for new players

• 💡Always read what Afflictions do before accepting them — some are build-breaking
• 💡Keep Resolve high — it's more important than grabbing every Gold room
• 💡A completed Sanctum run (all 4 floors) gives significantly better rewards
• 💡Sanctum is harder in HC-adjacent configs — practice in SC first

External resources